Metabolic Health
GLP-1 and Inflammation
Semaglutide measurably lowers a key inflammation marker in trial data, independent of how much weight is lost. Here is w...
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Metabolic Health
Insulin resistance, metabolism, blood sugar and the metabolic drivers of stubborn weight gain.
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Metabolic Health
Weight Loss and Life Expectancy
Obesity is linked to reduced life expectancy through several major disease pathways. Here is what large trial data shows...
Metabolic Health
Prediabetes and Weight
Prediabetes is a genuine warning stage where weight loss can meaningfully change the trajectory. Here is what it means a...
Metabolic Health
Breathlessness and Excess Weight
Breathlessness during ordinary activity is a common experience of excess weight with several identifiable mechanisms. He...
Metabolic Health
Rebound Weight Gain After Stopping GLP-1 Medication
Most weight comes back after stopping GLP-1 drugs, and the trial data shows how much. Here is why it happens and what ac...
Metabolic Health
GLP-1 Drugs and Heart Health
SELECT showed semaglutide cut cardiovascular events in people with obesity and no diabetes. Here is what that trial esta...
Metabolic Health
Weight Loss and Sleep Apnea
A phase 3 trial found tirzepatide reduced apnea events, hypoxic burden and blood pressure in people with obesity and sle...
Metabolic Health
GLP-1 and Fatty Liver Disease
The FDA approved semaglutide for MASH with fibrosis in August 2025 after the ESSENCE trial. Fatty liver is common in Sou...
Metabolic Health
Weight Loss, Blood Pressure and Cholesterol
Blood pressure and lipids improve early during weight loss, often enough that existing medication needs reducing. Here i...